Systematic profiling of alternative splicing events and splicing factors in left- and right-sided colon cancer

Xiaoliang Huang; Jungang Liu; Xianwei Mo; Haizhou Liu; Chunyin Wei; Lingxu Huang; Jianhong Chen; Chao Tian; Yongsheng Meng; Guo Wu; Weishun Xie; Franco Jeen P.C.; Zujun Liu; Weizhong Tang

doi:doi:10.18632/aging.102319

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Research Paper Volume 11, Issue 19 pp 8270—8293

Systematic profiling of alternative splicing events and splicing factors in left- and right-sided colon cancer

Figure 1. Overview of AS event profiling in left- and right-sided colon cancer. (A) Illustration of the seven types of AS events: Exon Skip (ES), Mutually Exclusive Exons (ME), Retained Intron (RI), Alternate Promoter (AP), Alternate Terminator (AT), Alternate Donor site (AD) and Alternate Acceptor site (AA). (B) The number of AS events and involved genes for each AS type in the 434 colon cancer patients. (C) The number of (DEAS events upregulated in left- or right-sided colon cancer. (D) UpSet plot of overlapping genes among the seven patterns of DEAS events that were upregulated in right-sided colon cancer. One gene may have up to three splicing patterns. (E) UpSet plot of overlapping genes among the seven patterns of DEAS events that were upregulated in left-sided colon cancer.