<i>CircNF1-419</i> improves the gut microbiome structure and function in AD-like mice

Chen Diling; Qi Longkai; Guo Yinrui; Liu Yadi; Tang Xiaocui; Zhu Xiangxiang; Zeng Miao; Li Ran; Shuai Ou; Wang Dongdong; Xie Yizhen; Yuan Xujiang; Burton B. Yang; Wu Qingping

doi:doi:10.18632/aging.102614

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This article is currently undergoing investigation.

Research Paper Volume 12, Issue 1 pp 260—287

CircNF1-419 improves the gut microbiome structure and function in AD-like mice

Figure 6. Circ0001239 changes the gut microbiota genetic trajectory in new born mice. (A) The alpha diversity (A) and beta diversity (B) of the gut microbiota when the circ0001239 over expressed in brain, see also in Supplementary Figure 6. (C) The ternary phase diagram showed that the most of the bacteria were closed to the circ_0001239 group. (D) The relative abundance of different bacteria when the circ0001239 over expressed in brain (LDA < 3.5). Data are presented as the means ± SD of 8 independent experiments. ^*p <0.05 and ^**p < 0.01 vs. the model group by one-way ANOVA, followed by the Holm-Sidak test.