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Research Paper Volume 12, Issue 2 pp 1778—1791
LncRNA DANCR attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through regulating of miR-33a-5p/XBP1s
Figure 6. Silencing of XBP1s reversed the effect of DANCR on proliferation and angiogenesis of OGD-treated BMECs. (A) Proliferation was measured by MTS after co-transfection with DANCR-pcDNA3.1 and si-XBP1 at 48 h, followed by OGD treatment for 4 h. (B–D) The bar represents the apoptotic rate (B), migratory cells (C), and number of meshes (D). (E) A representative image of apoptosis, migration (scale bar: 200×), and angiogenesis (scale bar: 200×), measured by flow cytometry, transwell, and tube formation assay, respectively, after co-transfection with DANCR-pcDNA3.1 and si-XBP1 at 48 h, followed by OGD treatment for 4 h. ***P<0.001 vs ov-NC.