Identifying lncRNA–miRNA–mRNA networks to investigate Alzheimer’s disease pathogenesis and therapy strategy

Nana Ma; Changrui Tie; Bo Yu; Wei Zhang; Jun Wan

doi:doi:10.18632/aging.102785

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Research Paper Volume 12, Issue 3 pp 2897—2920

Identifying lncRNA–miRNA–mRNA networks to investigate Alzheimer’s disease pathogenesis and therapy strategy

Figure 8. Gene Ontology (GO) enrichment annotations of the pathological progression of AD: biological process, cellular component, molecular function. The top terms were synapse (GO:0045202), cytoskeleton (GO:0005856), postsynaptic density (GO:0014069), cell-cell adherens junction (GO:0005913), dendrite (GO:0030425), axon (GO:0030424), and neuron projection (GO:0043005). (A) 6yes9no group, (B) 6no9yes group, and (C) 6yes9yes group. Significantly enriched GO pathways were defined as p values of <0.01. GO analysis was conducted with DAVID (https://david.ncifcrf.gov/summary.jsp) database.