Supplementary Figure 1. The function of hsa_circ_0006948 in ESCC cells. (A) Expression of hsa_circ_0006948 and FNDC3B mRNA in KYSE30 cells transfected with siRNAs and (B) TE-1 cells overexpressing hsa_circ_0006948. (C and D) The effect of hsa_circ_0006948 on cell proliferation in vitro using colony formation assay and CCK8 assay after knocking down hsa_circ_0006948 in KYSE30. (E) Cell migration and invasion abilities were assessed by transwell assay after knocking down hsa_circ_0006948 in KYSE30 cells. (F and G) The effect of hsa_circ_0006948 on cell proliferation in vitro using colony formation assay and CCK8 assay after overexpressing hsa_circ_0006948 in TE-1 cells. (H) Cell migration and invasion abilities were assessed by transwell assay after overexpressing hsa_circ_0006948 in TE-1 cells.* P<0.05, **P<0.01, ***P<0.001.