Figure 5. MOTS-c muscle protein or small mRNA expression does not correlate well with antioxidant-response element (ARE) related genes. Correlation between MOTS-c protein (A–D) or small mRNA (E–H) expression and mRNA levels of NFE2L2, HMOX1, NQO1 and SOD2 in muscle samples from young, middle-aged and older men. Significance was determined using linear regression for n=78 (protein correlations) or n=52 (MOTS-c mRNA correlations).