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Research Paper Volume 12, Issue 9 pp 7945—7962

Osthole alleviates neuropathic pain in mice by inhibiting the P2Y1-receptor-dependent JNK signaling pathway

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Figure 8. Osthole exerts analgesic effect by directly acting on P2Y1 receptor of astrocyte. (A) P2Y1R expression in transfected cells markedly increase compared to normal astrocyte. (B) Astrocyte-conditioned medium induced the change trend of c-Fos consistent with that of P2Y1R. ###p<0.01, compared with sham group; ***p<0.01, compared with P2Y1R overexpression group, ANOVA followed by Bonferroni post-hoc test, n=6 mice/group. All data are means ± S.D.