Research Paper Volume 12, Issue 9 pp 8241—8260

Figure 3. LncRNA-MALAT1 transferred by exosomes caused rejuvenation against Dox. (A) LncRNA-MALAT1 mRNA in cardiomyocytes was examined by qRT-PCR. ^*P < 0.05 versus Control; ^▲P < 0.05 versus Dox. (B) Cell cycle distribution was analyzed. (C and D) p53 and p21 mRNA levels were analyzed by RT-qPCR. (E) Representative images of SA-β-gal staining. (F) Percentage of β-gal-positive cells. Each column represents the mean ± SD of three independent experiments. ^*P < 0.05 versus control; ^▲P < 0.05 versus Dox; ^□P < 0.05 versus Dox + exosome^{Hypoxia+siRNA-lncRNA-MALAT1}.