Pluronic P123 modified nano micelles loaded with doxorubicin enhanced tumor-suppressing effect on drug-resistant breast cancer cells

Xiaoyu Zhang; Weibin Chen; Jie Bai; Lijun Jin; Xiaoning Kang; Hui Zhang; Zunyi Wang

doi:doi:10.18632/aging.103138

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This article is currently undergoing investigation.

Research Paper Volume 12, Issue 9 pp 8289—8300

Pluronic P123 modified nano micelles loaded with doxorubicin enhanced tumor-suppressing effect on drug-resistant breast cancer cells

Figure 1. Characterization of P123-PEG2000-DSPE (Dox). (A) The morphological characteristics of P123-PEG2000-DSPE (Dox) observed by transmission electron microscope. (B) Size distributions of P123-PEG2000-DSPE (Dox) determined by dynamic light scattering. (C) Cumulative drug release profiling of PEG2000-DSPE (Dox) and P123-PEG2000-DSPE (Dox) in phosphate-buffer saline (PBS, pH 7.4 and pH 5.0).