Pluronic P123 modified nano micelles loaded with doxorubicin enhanced tumor-suppressing effect on drug-resistant breast cancer cells

Xiaoyu Zhang; Weibin Chen; Jie Bai; Lijun Jin; Xiaoning Kang; Hui Zhang; Zunyi Wang

doi:doi:10.18632/aging.103138

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This article is currently undergoing investigation.

Research Paper Volume 12, Issue 9 pp 8289—8300

Pluronic P123 modified nano micelles loaded with doxorubicin enhanced tumor-suppressing effect on drug-resistant breast cancer cells

Figure 6. P123-PEG2000-DSPE (Dox) induced cell apoptosis in MCF-7R cells. Cell apoptosis rate of MCF-7R cells treated with PBS (control), Dox, PEG2000-DSPE (Dox) or P123-PEG2000-DSPE (Dox) by flow cytometry analysis. **P < 0.01 and ***P < 0.001 vs. control group; ^###P < 0.001 vs. Dox group; ^&&P < 0.01 vs. PEG2000-DSPE (Dox) group.