Research Paper Volume 12, Issue 9 pp 8652—8668
Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss
Figure 5. Effects of CDH-13 on age-related bone loss in the distal femurs of old mice. (A) Schematic representation of the experimental timeline for administering the vehicle (n = 5) or CDH-13 (n = 5) to 15-month-old mice. Changes in body weight (B) and dietary consumption (C) in the vehicle- and CDH-13-injected mice. (D) Representative micro-CT images of sagittal (upper) and transverse (lower) views of the distal femurs of vehicle- and CDH-13-injected mice. Histomorphometric analyses of (E) BMD, (F) bone volume, (G) trabecular bone volume over tissue volume, (H) bone surface area over bone volume, (I) trabecular thickness, (J) trabecular separation and (K) trabecular number in femurs from vehicle- and CDH-13-injected mice. Error bars represent ± SEM. ** P < 0.01, * P < 0.05.