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Research Paper Volume 12, Issue 14 pp 14157—14173
Circular RNA hsa_circ_0000073 contributes to osteosarcoma cell proliferation, migration, invasion and methotrexate resistance by sponging miR-145-5p and miR-151-3p and upregulating NRAS
Figure 7. Knockdown of hsa_circ_0000073 prevented tumor growth of OS by regulating NRAS in vivo. (A) Collected tumors were exhibited after hsa_circ_0000073 knockdown. (B) After hsa_circ_0000073 knockdown, NRAS expression was assessed using IHC and western blot assays. Magnification, ×100; Scale bar=100 μm. (C) qRT-PCR analyses of hsa_circ_0000073, miR-145-5p and miR-151-3p. (D) A skeleton diagram is displayed. *P<0.05.