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Research Paper Volume 12, Issue 14 pp 14391—14405
The cross-talk between DDR1 and STAT3 promotes the development of hepatocellular carcinoma
Figure 1. Expression of DDR1 in HCC tissue and cells. (A) The expression of DDR1 in clinical HCC tissues (n = 15) and adjacent normal tissues (n = 15) determined by qRT-PCR (**p<0.01). (B) Another HCC tissues from patients with tumor grade I (n = 8), grade II (n = 8) and grade III (n = 8) were collected, and the expression of DDR1 in was measured by qRT-PCR (*p<0.05). (C) The overall survival of HCC patients with low or high expression of DDR1 in HCC tissues were assessed by Kaplan-Meier survival analysis (n = 15, *p<0.05). qRT-PCR assay (D) and western blot (E) analyzed the expression of DDR1 in human hepatocyte (HH) and HCC cell lines Hep3B, HepG2, SK-Hep-1 and SNU-182 (n = 6, *p<0.05 vs HH).