Research Paper Volume 12, Issue 14 pp 14754—14774

Figure 1. Highly expressed DCTPP1 and QPRT in BC tissues compared to normal tissues. (A) A total of 935 genes, whose expression was different between BC and normal tissues, were screened from GSE42568, GSE65194, and TCGA expression datasets. (B) The expression correlation of these genes to the prognosis of patients with BC was analyzed using GEPIA web (http://gepia.cancer-pku.cn/). We found five protein-coding genes, including CCDC24, CD24, DCTPP1, QPRT, and SLC35A2, whose expression was correlated with BC prognosis. DCTPP1 and QPRT expression levels in BC and normal breast tissues were tested using PCR (C), western blot (D) and IHC assays (E). DCTPP1 and QPRT expression levels were confirmed to be higher in BC tissues than in normal breast tissues. *P < 0.05 and **P < 0.01 vs. normal breast tissues. N: normal breast tissues; T: breast tumor tissues.