Research Paper Volume 12, Issue 19 pp 18982—19011
POC1A acts as a promising prognostic biomarker associated with high tumor immune cell infiltration in gastric cancer
POC1A could impact immune infiltration significantly. (A) Copy number alteration (CNA) of POC1A was significantly correlated with immune infiltration levels of several immune cell types in GC. Deletion was found to have a highly reliable significant correlation with the infiltration level in neutrophils and dendritic cells (p<0.001), and arm-level gain was related to the infiltration level of macrophages with high reliability (p<0.001). (B) In the TIMER database, scatterplots of strong (|r|>0.5) and significant (p<0.001) correlations between POC1A expression and 7 immune genes (CCNB1, ESCO2, EXO1, KIF11, NUF2, PRC1, CCL14) after adjusting for purity. (C) In the GEPIA database, scatterplots of correlations between POC1A expression and 7 immune genes from TIMER. (D) Expression of POC1A in different immune subtypes of GC. (E) ENTPD1 had a strong significant correlation with POC1A (r=-0.51, p<0.001).