Research Paper Volume 12, Issue 19 pp 19012—19021
Apremilast ameliorates ox-LDL-induced endothelial dysfunction mediated by KLF6
Apremilast reduced ox-LDL-induced expression of LOX-1 in HUVECs. Cells were treated with ox-LDL (100 μg/mL) in the presence or absence of apremilast (0.5, 1 μM) for 24 h. (A) mRNA of LOX-1; (B) Protein of LOX-1 (****, P<0.0001 vs. non-treatment group; $$, $$$, P<0.01, 0.001 vs. ox-LDL group, n=4-5).