Research Paper Volume 12, Issue 19 pp 19012—19021
Apremilast ameliorates ox-LDL-induced endothelial dysfunction mediated by KLF6
The protective effects of apremilast against ox-LDL-induced attachment of monocytes to HUVECs were mediated by KLF6. HUVECs were transfected with KLF6 siRNA. (A, B) Real time PCR and western blot analysis revealed successful knockdown of KLF6; (C) Protein of MCP-1 and VCAM-1; (D) Attachment of U937 monocytes to HUVECs (****, P<0.0001 vs. non-treatment group; $$, P<0.01 vs. ox-LDL treatment group; ####, P<0.0001 vs. ox-LDL+ group, n=4-5).