Research Paper Volume 12, Issue 19 pp 19365—19374

Knockdown of NHP2 suppresses tumor growth in xenograft model injected with or without HBx-overexpressed PLC/PRF5 hepatoma cells. (A–C) After PLC/PRF5 cell lines with or without HBx upregulation were injected into the nude mice, the body weight (B) and the tumor volume (C) were measured every three day and plotted as the mean ± SD (n = 7); ^*** P < 0.001 vs con + shRNA-NC, ^#P<0.05 and ^###P < 0.001 vs ov-HBx + shRNA-NC. (D, E) At the 21 day after first injection, the tumors were isolated, the tumor weight was weighed. ^*P<0.05 and ^**P<0.01.