Research Paper Volume 12, Issue 22 pp 22656—22687

Figure 7. DDX21 promoting cell proliferation regulated by LncRNA-ZFAS1 in vivo. (A) Schematic diagram of xenografts in BALB/c nude mice by inoculating SW620 cells that were stably co-transfected with shZFAS1, shZFAS1+ pcDH-DDX21, shNC (empty-vector), and shZFAS1+NC at their right armpits. (B) Mean xenografts tumor weight for each group was determined on the 30^th day. Data are shown as mean ± s.d., n = 5 for each group. (C) Mean tumor volumes on different days for each group xenografts in nude mice. (D and E) Representative xenograft mice and tumors excised on the 30^th day are shown. (F) qPCR assays were performed to determine the mRNA expression of DDX21 and POLR1B above each group. The groups were as follows: shNC (empty vector); shZS1 (shZFAS1#1); shZS1+NC (co-transfected with shRNA and pcDH empty vector); shZS1+X21 (co-transfected with shZFAS1 and pcDH-DDX21).*, P <0.05; **, P <0.01; ***, P <0.001; **** P <0.0001.