Research Paper Volume 12, Issue 19 pp 19546—19562
Comparison of exosomes derived from induced pluripotent stem cells and mesenchymal stem cells as therapeutic nanoparticles for treatment of corneal epithelial defects
Proposed underlying mechanisms of iPSCs/MSCs-Exos in corneal epithelial defect healing. We propose that both iPSCs-Exos and MSCs-Exos can promote corneal epithelial repair and regeneration by enhancing HCECs proliferation, migration, promoting cell cycle development and attenuating apoptosis. iPSCs-Exos showed stronger effect on HCECs than MSCs-Exos in all aspects.