Research Paper Volume 12, Issue 21 pp 21504—21517

Figure 3. Models’ comparison on the DREAM challenge dataset. (A) The precision at top 5%, 10%, 15%, 20% ranked combinational scenarios of H-RACS, RACS and DIGRE; (B) The sensitivity at top 5%, 10%, 15%, 20% ranked combinational scenarios, and overall accuracy of H-RACS, RACS and DIGRE; (C) The overall accuracy of H-RACS, RACS and DIGRE; (D–F) The detailed ranking agreement between the predicted results and DREAM experimental results, The red dots are true synergistic drug combinations, while the blue dots are the non-synergistic ones confirmed from DREAM experiments. The vertical black dashed lines indicate the boundary between the top 16 synergistic pairs and non-synergistic ones, while the horizontal black dashed line illustrates the boundary between the top 16 predicted ranking and the rest 62 ones.