Research Paper Volume 12, Issue 19 pp 18889—18906

Age-related adaptations in frontocortical gene expression are perturbed in context of SNCA overexpression. (A) Schematic diagram of experimental groups highlighting differentially expressed genes between 5- and 12-month-old rats using the same significance cut-offs of p_adj ≤ 0.1 and │log₂FC│≥ 0.5 as above. (B) Venn diagram comparing DEGs identified in WT and TG rats between 5 and 12 months of age. (C) Partitioning of 1706 DEGs based on their gene expression in 5- and 12-month-old WT and TG rats. Subplots show expression medoids (± SD) of eight primary gene clusters grouped into four classes. Cluster cardinalities indicated.