Research Paper Volume 12, Issue 19 pp 18889—18906
Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson’s disease patients
Validation of oligodendrocyte-associated gene expression changes using RT-qPCR. (A) RNA-seq results of shared oligodendrocyte-specific targets were verified by RT-qPCR in rats. RT-qPCR normalized quantities shown relative to WT with individual data points plotted with mean ± SEM. Significances based on unpaired two-tailed t-tests with *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. (B) RNA-seq results of shared oligodendrocyte-specific targets were verified by RT-qPCR in human. RT-qPCR normalized quantities shown relative to controls with individual data points plotted with mean ± SEM. Circles represent females, rectangles males. Significances based on unpaired two-tailed t-tests with *p < 0.05.