Research Paper Volume 12, Issue 19 pp 18889—18906
Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson’s disease patients
Genotype- and age-related perturbations in gene activity cause increase of myelin-linked genes in rats overexpressing SNCA and PD patients. (A) Left panel shows heatmap of expression changes in frontal cortex of PD patients relative to healthy controls for shared DEGs attributed to oligodendrocytes. Right panel shows hierarchically clustered rat expression changes (relative to WT5m) for the same DEGs. (B) Rat and human expression changes of PLP1 and MAG across experimental groups plotted as individual data points with mean ± SEM. For human data, circles represent females, rectangles males.