Research Paper Volume 12, Issue 19 pp 19660—19676
Anticancer effects of miR-124 delivered by BM-MSC derived exosomes on cell proliferation, epithelial mesenchymal transition, and chemotherapy sensitivity of pancreatic cancer cells
MiR-124 expression was downregulated and the expression of EZH2 was stimulated in pancreatic cancer tissues and cell lines. Relative expression levels of miRNA-124 or EZH2 in pancreatic cancer tissues (A) or pancreatic cancer cell lines (B) AsPC-1, PANC1, BxPC-3 and sw1990, and pancreatic duct epithelial cell line HPDE6 were determined by qRT-PCR or western blot. The results were presented as the mean ± standard deviation (SD) of three independent experiments. ***P<0.001, compared with normal tissues or HPDE6 cell lines.