Research Paper Volume 12, Issue 19 pp 19740—19755
Development of a five-protein signature for predicting the prognosis of head and neck squamous cell carcinoma
Identification of the overall survival (OS)-associated proteins in the TCPA discovery cohort. (A) Volcano plot of proteins that are significantly associated with OS of HNSCC. Y-axis indicates the p values (-log10 scale), whereas the X-axis shows the hazard ratio (log2 scale). Each symbol represents a different protein, and the dark red and green symbols categorize the risky (n=13) and protective (n=20) proteins, respectively. (B) Tuning parameter (logλ) selection cross-validation error curve for OS-associated proteins. The vertical dotted line is drawn at the optimal value by the minimum criteria and the 1-SE criteria. (C) The LASSO coefficient profile of 6 OS-related proteins and the vertical dotted line is drawn at the value chosen by 10-fold cross-validation. (D) Multivariate Cox proportional hazards regression analysis reveals five independent prognostic proteins of HNSCC patients in the discovery cohort.