Research Paper Volume 12, Issue 19 pp 19740—19755

Validation of the protein-based prognostic signature with the TCPA validation cohort. (A) The distribution of risk scores in the low and high-risk groups. The risk scores for all patients in the validation cohort are plotted in ascending order and are divided by the threshold (vertical dotted line). The green and dark red dots belong to the low and high-risk groups, respectively. The risk scores are gradually increased from the low-risk group to high-risk group. (B) The pattern of survival time and survival status in low and high-risk groups. The dots in the left and right side of the vertical dotted line indicate the patients in the low and high-risk group, respectively. The dark red and green dots represent death and survival, respectively. The mortality rate is markedly higher in the high-risk group than in the low-risk group. (C) The expression levels of the five prognostic proteins for each patient in the validation cohort. The dark red color is indicative of higher relative expression and the green color represents lower expression (D) Survival analysis of the association between risk score and OS of HNSCC in the validation cohort. The OS is significantly shorter in patients in the high-risk group than those in the low-risk group.