Deubiquitinase USP7 regulates <i>Drosophila</i> aging through ubiquitination and autophagy

Lang Cui; Wenhao Song; Yao Zeng; Qi Wu; Ziqiang Fan; Tiantian Huang; Bo Zeng; Mingwang Zhang; Qingyong Ni; Yan Li; Tao Wang; Diyan Li; Xueping Mao; Ting Lian; Deying Yang; Mingyao Yang; Xiaolan Fan

doi:doi:10.18632/aging.104067

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Research Paper Volume 12, Issue 22 pp 23082—23095

Deubiquitinase USP7 regulates Drosophila aging through ubiquitination and autophagy

Figure 4. Effect of dusp7 knockdown on Drosophila stress tolerance. (A) Effect of dusp7 knockdown on Drosophila tolerance to H₂O₂. (B) Effect of gut-specific dusp7 knockdown on Drosophila tolerance to H₂O₂. (C) Effect of dusp7 knockdown on Drosophila tolerance to paraquat. (D) Effect of gut-specific dusp7 knockdown on Drosophila tolerance to paraquat. (E) Effect of dusp7 knockdown on Drosophila tolerance to starvation. (F) Effect of gut-specific dusp7 knockdown on Drosophila tolerance to starvation. (G) Effect of dusp7 knockdown on Drosophila tolerance to heat stimulation. (H) Effect of dusp7 gut-specific knockdown on Drosophila tolerance to heat stimulation. (>: hybridization).