Research Paper Volume 12, Issue 23 pp 23960—23973
The long noncoding RNA HCG18 participates in PM2.5-mediated vascular endothelial barrier dysfunction
Figure 2. LncRNA HCG18 acts as a ceRNA for miR-21-5p. (A) HCG18 was enriched in AGO2 RIP samples. (B). MiR-21-5p was enriched in AGO2 RIP samples. (C) The binding relationship between HCG18 and miR-21-5p was predicted by DIANA. (D) The binding relationship between HCG18 and miR-21-5p was determined by Dual-luciferase reporter assay. (E) The interaction between HCG18 and miR-21-5p in PM2.5-treated HUVECs was analyzed by qRT-PCR. *: P<0.05; **: P<0.01; ***: P<0.001.