ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials, and the World Health Organization International Clinical Trials Registry Platform, and international registers for published and unpublished double-blind randomized controlled trials from database inception to July 20, 2019. The pooled estimates of hazard ratios (HR) with 95% credible intervals (CrIs) were calculated for PFS, OS, and the time to deterioration of quality of life (QoL). The pooled estimates of odds ratio (OR) with 95% CrIs were calculated for ORR, AEs, and treatment discontinuation. This study is registered with PROSPERO (CRD42019138939)." name="description"> Comparative efficacy, safety, and acceptability of single-agent poly (ADP-ribose) polymerase (PARP) inhibitors in BRCA-mutated HER2-negative metastatic or advanced breast cancer: a network meta-analysis - Figure f4 | Aging
← Back
Research Paper Volume 13, Issue 1 pp 450—459

Comparative efficacy, safety, and acceptability of single-agent poly (ADP-ribose) polymerase (PARP) inhibitors in BRCA-mutated HER2-negative metastatic or advanced breast cancer: a network meta-analysis

class="figure-viewer-img"

Figure 4. Forest plots comparing PFS for talazoparib, olaparib, and TPC (subgroup analysis). (A) Hormone receptor–positive patients; (B) patients with TNBC; (C) patients with prior platinum; (D) patients with no prior platinum; (E) patients with BRCA1 mutation; (F) patients with BRCA2 mutation; (G) patients who received no prior chemotherapy.