Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI

Sergio Casta&#xF1;eda-Zegarra; Qindong Zhang; Amin Alirezaylavasani; Marion Fernandez-Berrocal; Rouan Yao; Valentyn Oksenych

doi:doi:10.18632/aging.202346

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Research Paper Volume 12, Issue 23 pp 23578—23597

Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI

Figure 3. Development of B and T cells in Paxx^-/-Mri^-/- mice. (A) Number of thirty-day-old mice (P30) of indicated genotypes. Parents were Paxx^+/-Mri^+/- and Paxx^-/-Mri^+/-. (B) Example of thirty-day-old Paxx^-/-Mri^-/- and WT male littermates with their respective thymi and spleens. (C) Example of flow cytometry analyzes of B and T cells in Paxx^-/-Mri^-/- and WT mice. (D, E) Class switching analyzes of in vitro activated naïve B cells of indicated genotypes.