Obesity induced by high-fat diet is associated with critical changes in biological and molecular functions of mesenchymal stromal cells present in visceral adipose tissue

Mustafa Burak Acar; &#x15E;erife Ayaz-G&#xFC;ner; Giovanni Di Bernardo; H&#xFC;seyin G&#xFC;ner; Ay&#x15F;eg&#xFC;l Murat; Gianfranco Peluso; Servet &#xD6;zcan; Umberto Galderisi

doi:doi:10.18632/aging.202423

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Research Paper Volume 12, Issue 24 pp 24894—24913

Obesity induced by high-fat diet is associated with critical changes in biological and molecular functions of mesenchymal stromal cells present in visceral adipose tissue

Figure 6. Overexpressed proteins in HFD-MSCs associated with senescence. The picture shows the overexpressed (in red) and downregulated (in black) proteins in the proteomes and secretomes of HFD-MSCs compared to ND-MSCs. The differences in expression are expressed as LogFC. The column “Upregulated in senescence” indicates the proteins for which expression is upregulated in senescent cells, according to SeneQuest (https://senequest.net) and PubMed (https://pubmed.ncbi.nlm.nih.gov).