Research Paper Volume 13, Issue 5 pp 6681—6701
Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy
Figure 8. Indoxyl sulfate decreased antioxidant enzyme activities. Unilateral nephrectomized mice were intraperitoneally injected with indoxyl sulfate (IS, 0 and 100 mg/kg) and the indoxyl sulfate-injected mice were orally given with AST-120 (0 and 400 mg/kg) for 7 weeks. The prefrontal cortical tissues were collected and subjected to the measurement of Mn-SOD activity, Cu/Zn-SOD activity, Catalase activity, and GPx activity. *p < 0.05 vs. control group, and #p < 0.05 vs. indoxyl sulfate alone (IS) group, n = 8.