Transcription factor ELK1 accelerates aerobic glycolysis to enhance osteosarcoma chemoresistance through miR-134/PTBP1 signaling cascade

Qiang Zhang; Jiaqi Wu; Xiangfeng Zhang; Le Cao; Yongping Wu; Xudong Miao

doi:doi:10.18632/aging.202538

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Research Paper Volume 13, Issue 5 pp 6804—6819

Transcription factor ELK1 accelerates aerobic glycolysis to enhance osteosarcoma chemoresistance through miR-134/PTBP1 signaling cascade

Figure 1. ELK1 may promote PTBP1 expression by downregulating miR-134 to participate in the chemotherapeutic resistance of osteosarcoma. (A) The boxplot of PTBP1 expression in osteosarcoma-related microarray data GSE12805 from GEO database (https://www.ncbi.nlm.nih.gov/geo/). (B) The intersection between the predicted results of miRNAs that regulated PTBP1 and differential analysis in microarray data GSE28423 through StarBase database (https://web.archive.org/web/20110222111721/http://starbase.sysu.edu.cn/). (C) The boxplot of miR-134 expression in osteosarcoma-related microarray data GSE12805. (D) The binding sites between miR-134 and PTBP1. (E) The boxplot of ELK1 expression in osteosarcoma-related microarray data GSE12805.