Fecal microbiota transplantation mitigates vaginal atrophy in ovariectomized mice

Jia Huang; Wanying Shan; Fuxia Li; Zizhuo Wang; Jing Cheng; Funian Lu; Ensong Guo; Rajluxmee Beejadhursing; Rourou Xiao; Chen Liu; Bin Yang; Xi Li; Yu Fu; Ling Xi; Shixuan Wang; Ding Ma; Gang Chen; Chaoyang Sun

doi:doi:10.18632/aging.202627

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Research Paper Volume 13, Issue 5 pp 7589—7607

Fecal microbiota transplantation mitigates vaginal atrophy in ovariectomized mice

Figure 5. Gut microbiota analysis for mice received fecal microbiota and normal saline lavage. (A) Wayne diagram analysis based on OTU for OVX+FMT (n=11), OVX+NST (n=11), Sham+FMT (n=10) and Sham+NST (n=9) groups. (B) Shannon diversity index among OVX+FMT (n=11), OVX+NST (n=11), Sham+FMT (n=10) and Sham+NST (n=9) (one-way ANOVA, F_{3, 37}=6.86, P=0.001) (C) Simpson diversity index among OVX+FMT (n=11), OVX+NST (n=11), Sham+FMT (n=10) and Sham+NST (n=9) groups (one-way ANOVA, F_{3, 37}=8.35, P<0.001). (D, E) β-diversity analysis including PCA and OTU based PLS-DA for OVX+FMT (n=11), OVX+NST (n=11), Sham+FMT (n=10) and Sham+NST (n=9) groups. (F, G) Significant differences analysis among OVX+FMT (n=11), OVX+NST (n=11), Sham+FMT (n=10) and Sham+NST (n=9) groups by linear discriminant analysis Effect Size (LEfSe) analysis.