Figure 4. ZD promoted the inflammation. (A) ZD induced the protein pro-inflammatory mediators in the colon. CCL2, CXCL2, CXCL5, IL-1β, IL6, and TNF-α protein were measured by ELISA. (B) ZD induced the protein pro-inflammatory mediators in serum. CCL2, CXCL2, CXCL5, IL-1β, IL6, and TNF-α protein were measured by ELISA. Horizontal bars indicated the average protein levels. *P < 0.05, **P < 0.01, and ***P < 0.001 vs ZS group, n=6.