COVID-19 Research Paper Volume 13, Issue 7 pp 9160—9185

TMBIM6, a potential virus target protein identified by integrated multiomics data analysis in SARS-CoV-2-infected host cells


Figure 6. A proposed working model for the apoptosis of host cells infected with SARS-CoV-2. Possible mechanisms of host cell apoptosis induced by SARS-CoV-2 through translational inhibition of TMBIM6. TMBIM6 is a multifunctional protein that can inhibit the activation of BAX, ROS production and Ca2+ release from the ER. Upon SARS-CoV-2 infection, downregulated TMBIM6 promotes the release of Ca2+ and ROS accumulation in mitochondria, which leads to the release of proapoptotic factors. In addition, downregulation of TMBIM6 relieves its inhibition of BAX activation, thus leading to host cell apoptosis.