mTOR inhibition improves mitochondria function/biogenesis and delays cardiovascular aging in kidney transplant recipients with chronic graft dysfunction

Barbara Infante; Francesco Bellanti; Michele Correale; Paola Pontrelli; Rossana Franzin; Serena Leo; Martina Calvaruso; Silvia Mercuri; Giuseppe Stefano Netti; Elena Ranieri; Natale Daniele Brunetti; Giuseppe Grandaliano; Loreto Gesualdo; Gaetano Serviddio; Giuseppe Castellano; Giovanni Stallone

doi:doi:10.18632/aging.202863

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Research Paper Volume 13, Issue 6 pp 8026—8039

mTOR inhibition improves mitochondria function/biogenesis and delays cardiovascular aging in kidney transplant recipients with chronic graft dysfunction

Figure 5. Serum levels of fluorescent hydroxynonenal- (HNE, A) and malondialdehyde- (MDA, B) protein adducts in patients treated with calcineurin inhibitor (CNi) or CNi + mTOR inhibitor (CNi+mTORi). AUF, arbitrary units of fluorescence.