Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress

Roc&#xED;o Brea; Pilar Valdecantos; Patricia Rada; Rosa Alen; Carmelo Garc&#xED;a-Monz&#xF3;n; Lisardo Bosc&#xE1;; Marina Fuertes-Agudo; Marta Casado; Paloma Mart&#xED;n-Sanz; &#xC1;ngela M. Valverde

doi:doi:10.18632/aging.202884

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Research Paper Volume 13, Issue 6 pp 7800—7827

Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress

Figure 6. Analysis of lymphoid populations in PBMCs from 2 m/o, 14 m/o and 14 m/o + APAP mice by flow cytometry. (A) Percentage of Cd8⁺ (left) and Cd4⁺ (right) from Cd45⁺Cd3⁺ cells. (B) Linear regression between populations in NPCs and PBMCs from 2 m/o, 14 m/o and 14 m/o + APAP mice. (C) Representative images of flow cytometry analysis. (D) Linear regression between Cd8⁺ cells (left) and Cd4⁺ cells (right) in PBMCs and the NAS score from 2 m/o, 14 m/o and 14 m/o + APAP mice. Data are represented as the mean ± S.E.M. (n = 7-11 mice per group). Statistical analysis was performed by Brown-Forsythe and Welch ANOVA test followed by their respective post-hoc test. ** P < 0.01 vs. 2 m/o; ^# P < 0.05 vs. 14 m/o.