Research Paper Volume 13, Issue 10 pp 13615—13625

Figure 8. The Piezo2 expression after IL-6 administration in the sham rats. Immunocytochemistry images show the expression of Pieao2 in Sham+saline (A) and Sham+IL-6 group (B) at day 7, which accounts for 19.8±6.1% vs. 35.2±9.2% (p<0.05) (C). Three days after local administration of recombinant rat IL-6 in those with sham operation, significant changes in mechanical threshold (D) as well as dynamic allodynia score (E) and pinprick hyperalgesia score (F) are observed.