Figure 4. The proportions of CAVD incident cases varied from 1990 to 2019 attributed to population growth, population aging, and epidemiological change in (A) the globe; (B) low SDI quintiles; (C) low-middle SDI quintiles; (D) middle SDI quintiles; (E) high-middle SDI quintiles; and (F) high SDI quintiles. Epidemiological change refers to the CAVD incident cases variation when age structure and population remained constant. CAVD, calcific aortic valve disease; SDI: socio-demographic index.