Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture

Weihan Wang; Hao Zhang; Changkai Hou; Quanlei Liu; Shuyuan Yang; Zhen Zhang; Weidong Yang; Xinyu Yang

doi:doi:10.18632/aging.202948

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Research Paper Volume 13, Issue 9 pp 12800—12816

Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture

Figure 2. Effects of recombinant protein ADAMTS-5 on the development of aneurysmal rupture in male mice. (A) Incidence of aneurysm and rupture rate in sham mice, control (CTRL) IA mice, and recombinant protein ADAMTS-5-administered (rADAMTS-5) IA mice. (B) Symptom-free curve (Kaplan-Meier analysis curve) demonstrated a significant increase in survival in the rADAMTS-5 treatment cohort (log-rank P<0.05). (C) Unruptured aneurysm. (D) No aneurysm. (E) Ruptured aneurysm. *P<0.05, **P<0.01.