Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture

Weihan Wang; Hao Zhang; Changkai Hou; Quanlei Liu; Shuyuan Yang; Zhen Zhang; Weidong Yang; Xinyu Yang

doi:doi:10.18632/aging.202948

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Research Paper Volume 13, Issue 9 pp 12800—12816

Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture

Figure 4. Effects of rADAMTS-5 on monocyte/macrophage infiltration and inflammatory mediators within the IA artery. (A) Immunostaining for macrophages (white arrow) with MOMA-2 (red) of arterial sections of the sham group, control group (CTRL), and rADAMTS-5-administered group. Scale bar, 40μm. (B) Effects of rADAMTS-5 treatment on the mRNA levels of inflammatory mediators. *P<0.05, **P<0.01.