Research Paper Volume 13, Issue 7 pp 9277—9329

Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis


Figure 5. Blood and cortex biomarkers showing opposite profiles in APOE2 and APOE4 strata. (A) Meta-analysis logFCs from case-control DE analysis in blood and cortex (APOE2 and APOE4 strata); (B) average expression of genes downregulated in APOE2 and upregulated in APOE4 cases by normal tissue (GTEx repository); (C) average expression of genes upregulated in APOE2 and downregulated in APOE4 cases by normal tissue (GTEx repository).