Research Paper Volume 13, Issue 10 pp 13822—13845

Figure 7. Gene methylation analysis of the gene signature between the tumor and normal tissues. (A) beneficial and harmful methylation sites in BDNF; (B) beneficial and harmful methylation sites in EOMES; (C) beneficial and harmful methylation sites in ZNF746 gene; (D) beneficial and harmful methylation sites in PIK3R1gene; (E) beneficial and harmful methylation sites in TSC2 gene; (F) beneficial and harmful methylation sites in MYCN gene; (G) The methylation of BDNF gene significantly correlated with the OS of HCC patients; (H) The methylation of PIK3R1 gene significantly correlated with the OS of HCC patients. HCC, hepatocellular carcinoma; OS, overall survival; ROC, receiver operating characteristic curve.