Research Paper Volume 13, Issue 10 pp 14065—14077
TCF-3-mediated transcription of lncRNA HNF1A-AS1 targeting oncostatin M expression inhibits epithelial-mesenchymal transition via TGFβ signaling in gastroenteropancreatic neuroendocrine neoplasms
Figure 4. HNF1A-AS1 inhibited GEP-NENs tumorigenesis in vivo. (A) The HNF1A-AS1 over-expression group or EV group were used for tumorigenesis assay. Five weeks later, the mice were killed and the tumor nodules were harvested. (B–C) Tumor growth curves after subcutaneous injection of QGP-1 cells transfected with HNF1A-AS1 over-expression plasmid or EV were shown. The tumor volumes and weights were measured every 7 days after inoculation. (D) qRT-PCR was performed to validate the higher level of HNF1A-AS1 in over-expression group than in EV group. *p < 0.05, **p < 0.01.