Research Paper Volume 13, Issue 16 pp 20050—20080

Figure 12. Differential expression profiles of genes participating mostly affected KEGG pathways according to the RNA-Seq data for MRC5-SV40 cell line treated with Abisil. Each cell demonstrates the sorted expression level log fold changes after Abisil treatment (red – upregulation, blue – downregulation) for genes participating a current KEGG pathway (vertical axis range is from 4-fold downregulation to 4-fold upregulation). Cell borders indicate whether a pathway is enriched with up- (red border) or downregulated (blue border) genes. GSEA min p (up/down-reg) – minimal p-value in a gene set enrichment analyses (GSEA; Fisher’s exact test) for the pathway. Hi vs Low – comparison of cells treated with 50 and 5 μg/ml; Hi vs Cnt – comparison of cells treated with Abisil 50 μg/ml and non-treated cells; Low vs Cnt – comparison of cells treated with Abisil 5 μg/ml and non-treated cells.