Figure 7. Inactivation of CDK4 or VWF inhibits the invasion and migration of melanoma. (A, B) Closure percentage of the si-CDK4 or si-VWF group was significantly lower than that of the Control and si-Control groups. (C, D) Relative count of invading cells of the si-CDK4 or si-VWF group was significantly lower than that of the Control and si-Control groups. Asterisks indicate statistically significant difference (**: p<0.01, one-way ANOVA).