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Research Paper Volume 13, Issue 21 pp 24171—24191

LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability

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Figure 1. The study design to identify an autophagy-related and genomic-instability-related lncRNA-miRNA-Gene pathway in breast cancer. mRNAs and lncRNAs are identified from RNA-seq data. the Human Autophagy Database (HADb: http://www.autophagy.lu) is used to identify autophagy-related genes. Univariate and multivariate Cox regressions are used to identified prognosis-related miRNA, and co-expression is used to identify prognosis-related miRNA. miRDB, miRTarBase, and TargetScan are used to recognize miRNA-targeted genes. LncBase 2.0 is used to identify lncRNAs that interact with miR-26a-5p. Co-expression analysis between lncRNA-genes and miRNA-genes is performed to identified lncRNA-miRNA-gene pathways.