Research Paper Volume 13, Issue 23 pp 25377—25392
Tartary buckwheat flavonoids relieve the tendency of mammary fibrosis induced by HFD during pregnancy and lactation
Figure 9. The effect of TBF on alleviating mammary fibrosis tendency and its underlying mechanism induced by HFD during pregnancy and lactation. HFD during pregnancy and lactation caused inflammation of mammary tissue, destroyed the blood-milk barrier, and induced fibrotic lesions tendency in mammary. TBF significantly alleviates the inflammatory response caused by HFD, repairs the blood-milk barrier, and relieves the tendency of mammary tissue fibrosis. Potential protective mechanism of TBF: TBF inhibited the activation of the AKT/NF-KB signaling pathway, effectively inhibiting the inflammatory response to the induction of fibrosis; TBF promoted the expression of tight junction proteins claudin-3, occluding, and ZO-1, and repairs blood-milk barrier to reduce the risk of mammary tissue being exposed; TBF inhibited the activation of TGF-β/Smad signal and inhibits the occurrence of fibrosis tendency.